PLASMA CORTISOL-LINKED GENE NETWORKS IN HEPATIC AND ADIPOSE TISSUES IMPLICATE CORTICOSTEROID-BINDING GLOBULIN IN MODULATING TISSUE GLUCOCORTICOID ACTION AND CARDIOVASCULAR RISK

Genome-wide association meta-analysis (GWAMA) by the Cortisol Network (CORNET) consortium identified genetic variants spanning the SERPINA6/SERPINA1 locus on chromosome 14 associated with morning plasma cortisol, cardiovascular disease (CVD), and SERPINA6 mRNA expression encoding corticosteroid-binding globulin (CBG) in the liver.These and other fi

Aim: It is aimed to compare clinical, radiological and computed tomography findings of knee joint lesions in terms of diagnosis.In addition, early diagnosis of cranial cruciate ligament defects were assessed for effectiveness of computed tomography.Materials and Methods: 12 medium / large dogs with different breed, sex, age and breed were used as s

Owing to the rising demand for vegetable soybean products, there is an increasing need for high-yield soybean varieties.However, the complex correlation patterns among quantitative traits with genetic Intimates Accessories architecture pose a challenge for improving vegetable soybean through breeding.Herein, a genome-wide association study (GWAS) w

BACKGROUND:The inverse association between education and mortality has grown stronger the last decades in many countries.During the same period, gains in life expectancy have been concentrated to older ages; still, old-age mortality is seldom the focus of attention when analyzing trends in the education-mortality gradient.It is further unknown if i

Powdery mildew disease (PMD) is caused by the obligate biotrophic fungus Microsphaera diffusa Cooke & Peck (M.diffusa) and results in significant yield losses in soybean (Glycine max (L.) Merr.) crops.By identifying disease-resistant genes and breeding soybean accessions with enhanced resistance, we can effectively mitigate the detrimental impa